HLA-Associated Cellular Response to GAD in Type 2 Diabetes with Antibodies to GAD.
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چکیده
منابع مشابه
The Presence of GAD and IA-2 Antibodies in Youth With a Type 2 Diabetes Phenotype
OBJECTIVE To determine the frequency of islet cell autoimmunity in youth clinically diagnosed with type 2 diabetes and describe associated clinical and laboratory findings. RESEARCH DESIGN AND METHODS Children (10-17 years) diagnosed with type 2 diabetes were screened for participation in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study. Measurements included G...
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The aim of the study was 1) to establish the prevalence of GAD antibodies (GADab) in a population-based study of type 2 diabetes in western Finland, 2) to genetically and phenotypically characterize this subgroup, and 3) to provide a definition for latent autoimmune diabetes in adults (LADA). The prevalence of GADab was 9.3% among 1,122 type 2 diabetic patients, 3.6% among 558 impaired glucose ...
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This 3-year prospective study enrolled 95 subjects from15 Chinese cities including 25 high-titer (GADA ‡180 units/mL) LADA patients, 42 low-titer (GADA <180 units/mL) LADA patients, and 28 type 2 diabetic patients, the latter two groups as controls of similar age, sex, andBMI. Clinical characteristicswere determined annually, including glycosylated hemoglobin (HbA1c), fasting C-peptide (FCP), a...
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The aim of our study was to evaluate antibodies against thyroglobulin (anti-TG) and thyroid peroxidase (anti-TPO) - markers of autoimmune thyroiditis - in several groups of adult patients with type 1 and type 2 diabetes mellitus (DM). We were particularly interested whether the presence of thyroid antibodies is related to the positivity of glutamic acid decarboxylase antibodies (anti-GAD). We f...
متن کاملParaneoplastic encephalomyelitis associated with pancreatic tumor and anti-GAD antibodies.
Glutamic acid decarboxylase (GAD), the enzyme that catalyzes the conversion of glutamate to -aminobutyric acid (GABA), is expressed in GABA-secreting neurons and pancreatic cells.1 Anti-GAD antibodies (GAD Abs) have been described in patients with type 1 diabetes mellitus and patients with two CNS disorders, stiff-person syndrome and cerebellar ataxia associated with polyendocrine autoimmunity....
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ژورنال
عنوان ژورنال: Endocrine Journal
سال: 2000
ISSN: 0918-8959,1348-4540
DOI: 10.1507/endocrj.47.753